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Experimental results have pointed out that supplementary treatment involving CN-Cbl leads to increased genome-wide DNA methylation and decreased expression of proinflammatory genes, such as IL-1 and CCL3, in neonatal rats affected by pneumococcal meningitis [112]

doi: 10.1126/sciimmunol.abd2071 148

doi: 10.1158/2159-8290.CD-22-0043 366

This unique property means both local and systemic administration can support healing, though local injection near the injury typically produces faster results

Oestrogen dependence may be due to the upregulation of the 17-hydroxysteroid dehydrogenase-1 and aromatase genes, whereas progesterone resistance may result from the failure of progesterone receptor activation and transcription of progesterone target genes [99]