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For truly related but very divergent proteins, it is often possible to identify locally conserved regions that are important for structure and/or function

1 Introduction Melasma is a common hyperpigmentation disorder, especially in the female gender, that is usually presented symmetrically as light brown to dark brown hyperpigmented spots in the face and also it can be exacerbated through prolonged sun exposure (Guarneri, 2014) with possible inflammatory features (Noh et al., 2014)

Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4

In turn, immune cells counteract these adaptations through metabolic activity, cytokine production, and direct cytotoxicity, potentially placing metabolic pressure on tumor mitochondria (Fig