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Bryer and Goldfarb observed that a 2-week vitamin C supplementation regimen in healthy males, followed by 4 days of eccentric exercise increased the oxidized glutathione (GSSG)/reduced glutathione (GSH) ratio, thereby preventing exercise-induced oxidative stress compared to the placebo group [29]

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Specifically, the compounds extensive biological activity should inherently entail an irreducible risk of unanticipated off-target or systemic adverse effects [1]

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