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This adverse effect on B12 status has only been implicated with synthetic folic acid and not with natural folate from food sources (i.e., methyltetrahydrofolate) (Selhub et al., 2022)

Mood Regulation: B12 plays a vital role in the synthesis of serotonin, helping to reduce anxiety and stabilize your mood

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I've never vomited I've felt nauseous with my symptoms but nor from injection The effects I've had are: Suddenly dripping off to sleek which I hate Headaches Tinnitus Blurry vision Sometimes an old symptom returns Not always and not all at one time and more atthe start I've never had any side effects & I've been self injecting every other day for 20 months now, as the 3 monthly one from my GP isn't enough for me

In another study, rats with diabetic kidney disease (DKD) were treated with a CD38 inhibitor, resulting in increased renal NAD + levels, which in turn decreased mitochondrial oxidative stress 144