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Subsequently, ribosomal protein S6 (RPS6), the subunit of eukaryotic translation initiation factor 2 (eIF2), and eukaryotic translation elongation factor 2 (eEF2) undergo phosphorylation (Dong et al., 2018)

The AnglV analog D-Nle-Tyr-Ile-NH-(CH 2 ) s -CONH 2 has a much longer circulating half- life than Norleual (Nle-Tyr-Leu-i^CHj-NH^-His-Pro-Phe (SEQ ID NO: 1)) As anticipated from the in- vitro blood stability data, D-Nle-Tyr-Ile-NH-(CH 2 )5- CONH 2 exhibited an extended in vivo elimination half-life of 1012 min after IV injection in rats

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The beneficial effect observed on tinnitus in this study is most likely attributed to the protective mechanisms of antioxidants contained in the supplements against ROS-induced cochlear hair cell damage

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