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Interestingly, GH signaling leading to activation of lipolysis in adipose tissue and increased hepatic glucose production via both glycogenolysis and gluconeogenesis in the liver, is not affected by the absence of insulin crosstalk (reviewed in (72))

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A 23-week randomized clinical trial found that participants taking 1 mg of AOD-9604 daily lost an average of 6.2 pounds compared to 1.8 pounds in the placebo group

Address correspondence to: Ramon Arens, Department of Immunology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands

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