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C., Loreto, F., Marco, G

Ice crystal formation physically damages the peptide structure, creating aggregation and reducing biological activity

In addition to the catalytic function of PCBD1, the protein serves as a transcriptional co-activator for two transcription factors of the hepatocyte nuclear factor-1 family, HNF-1 (encoded by the HNF1A gene) and HNF-1 (encoded by the HNF1B gene)

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M2 macrophages exhibit higher ferroportin levels, increased heme recycling, and robust glutathione synthesis, collectively establishing a ferroptosis-resistant environment that enables tumor progression and immune evasion