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BIO-PROTOCOL 6:e1984

We investigated whether diminished levels of a key mitochondrial antioxidant, glutathione (GSH), was contributing to defective fatty acid oxidation in older HIV-infected patients, and if so, the metabolic mechanisms contributing to GSH deficiency in these patients

Increased formation of the superoxide anion radical, which has been shown to impede CAT activity, may also be the cause of the decreased CAT activity (Snezhkina et al., 2019)

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As a control, we compared our crystal structures with the predicted models (Supplementary Fig