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Browner, Warren S

& Gurcan, M

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Upon activation by microbial PAMPs and other stress-related molecules, NLRP3 leads to the activation of caspase-1 followed by cleavage of pro-IL-1 into its active IL- form, which promotes further inflammatory signaling

norepinephrine increases both total peripheral resistance, as well as systolic and diastolic blood pressure Note : Compensatory vagal reflexes tend to overcome the direct positive chronotropic effects on the heart (since both branches of the ANS innervate the SA node), but do not eliminate the positive inotropic effects on the ventricle (which does not have significant vagal innervation)