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10.1016/j.redox.2020.101544 Redox Biol

These precursors can also be referred to as growth factors

Finally, ablation of the IGF-1R early in the OB lineage, using the osx promoter-driven Cre (Osx-IGF-IRKO), resulted in impaired chondrogenesis, secondary ossification, trabecular bone formation, and compromised linear bone growth [106]

The PERK-ATF4-CHOP pathway is a central signaling cascade activated in response to ER stress, serving as the cells primary reaction to dysfunction and playing a crucial role in cellular survival

Note: NGT = Normal glucose tolerance
