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Multicenter, dose escalation trial to determine the Safety, Tolerance, maximum tolerated dose and recommended phase 2 dose of DCR-MYC, a lipid nanoparticle (LNP)-Formulated small inhibitory RNA (siRNA) oligonucleotide targeting MYC, in patients with hepatocellular carcinoma (HCC)

J Neurosci 2019;39:5594-605

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[DOI] [PubMed] [Google Scholar] Huang ZZ, Yang HP, Chen CJ, Zeng ZH, Lu SC

Likely due to a multi-targeted approach where, in vitro, vitamin C serves as a potent free radical scavenger, while vitamin A protects against membrane damage due to its ability to disrupt lipid peroxidation (67, 68)