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Excitingly, combining JHU083 treatment with the EGFR peptide vaccine (EVAx) significantly inhibits lung tumor development, highlighting the potential synergy of this combination therapy in promoting tumor-specific immune responses mediated by adaptive T cells [185]

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82 The promising mechanism of action of TLK286 and its positive preclinical data have sparked a series of clinical trials where the prodrugs have been applied alone or in combination with other standard chemotherapeutic agents

Thus, in response to stress, ciRS-7 may be upregulated in malignant cells to initiate DNA repair and prevent apoptosis [475]

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