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In Cohort 1, 25 WT and 25 RAMP1/3 KO male mice aged 1220 weeks old were injected intraperitoneally after a 12-hour fast with vehicle, sCT at doses of 3 or 150 nmol/kg, or Cagrilintide at a dose of3 nmol/kg

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Scratch healing rate (%) = (C 0 C t )/C 0 100%, where C 0 represents the scratch area at 0 h and C t represents the scratch area at specific times

BPC-157 helps maintain the integrity of gut tissues, making them a subject of interest for research concerning gut health

Although NMR using fluorescent biosensors or optical reporter tags can provide a valuable perspective for identifying the biochemistry of living cells, it, like the MS based approach, is of limited use for in situ tracking of metabolic processes (Lerche et al., 2015), due to the inherent physicochemical properties of small and hydrophilic metabolites, such as low ionisation efficiency and high detection limits (Chalcraft et al., 2009