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These results indicate that the metabolic shift from glucose substrate-dependent pathway to FAO or glutaminolysis was induced under the exposure to H 2 O 2 regarding the mitochondrial damage, whereas the promotion was not enough to compensate respiratory capacity decrease and was rather a marker of H 2 O 2 -exposed stress, and this shift was held to the nearly normal state with PQQ pretreatment protection

In fact, acute L-Carnitine supplementation has led to lowered heart rates during exercise and improved endurance

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Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder