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It may reduce the absorption of oral medications by interacting with intestinal transporters, potentially affecting the bioavailability of drugs like metformin

Amyotroph Lateral Scler Other Mot Neuron Disord 2:918 Graf M, Ecker D, Horowski R et al (2005) High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study

doi: 10.1002/1873-3468.14268

Clinically, many IBS patients show signs of increased intestinal permeability, elevated levels of pro-inflammatory cytokines in the serum, and enhanced immune activation (81)

146 For those with the complex form of autism, retinoic acid supplementation during pregnancy might be better than retinol supplementation, but additional studies would need to identify definitive biomarkers to justify the use of retinoic acid as a supplement for a pregnant woman