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Synergy with Hyaluronic Acid (HA): When co-administered with HA, AOD 9604 demonstrated superior efficacy in reducing lameness and structural damage compared to either agent alone

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Interestingly, SC-D and ZPD-2 have been used as scaffolds to rationally design variants with enhanced activity or pharmacological properties [340,341]

[DOI] [PMC free article] [PubMed] [Google Scholar] 32.Nakasaki M, Yoshioka K, Miyamoto Y, Sasaki T, Yoshikawa H, Itoh K: IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts
