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The integration of these three approaches at the level of the same sample will become an important direction for advancing this field from mechanistic research toward clinical translation (140)

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Crocin has been proven to ameliorate cardiotoxicity via the KEAP1-NRF2/HO-1 pathway ( Figure 6B )

Some individuals report better results with this approach, particularly for GI conditions

Initially, HDACs are generally believed to preferentially target histones, whereas sirtuins exhibit a notable preference for non-histone components in the cytoplasm or within the nucleus, exhibiting complementary functions [51, 52]