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In addition, B12 deficiency-associated fatigue is often accompanied by other symptoms such as numbness and tingling, cognitive impairment (memory and concentration problems), mood swings (depression), skin changes (pale skin), shortness of breath, or fast heart rate

*Correspondence: Peter Schrder [email protected] This article was submitted to Plant Physiology, a section of the journal Frontiers in Plant Science Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

doi: 10.1038/s41586-022-05588-y

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Numerous studies have reported that inflammation may directly and indirectly affect lung endothelia and pulmonary hemodynamics by activating inflammatory cells, such as neutrophils, macrophages, and lymphocytes, and proinflammatory mediators [13]