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The antioxidant activity of GSH intermediated via thiol (-SH) of its cysteine residue upon its interaction with ROS or electrophiles and the GSH oxidized to GSSG (oxidized Glutathione), the GSSG will reduce to GSH by Glutathione reductase (GR), the activity of GR is therefore very important to keep the antioxidant power of mammalian cells, while GSH/GSSG ratio is an indicator for redox balance in the cell

Identification of an anionic form of glutathione transferase present in many human tumors and human tumor cell lines

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335 Astrocytes in post-mortem samples of patients with mesial temporal lobe epilepsy show significant down-regulation of K ir 4.1 channels critical for K + buffering