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The authors suggest a protective role of higher concentrations of SCN ions in the saliva of compulsive smokers

Circulation 112:10471053
Glutathione plays a crucial role in detoxifying cells, protecting against oxidative stress, and supporting immune function

In addition, other model organisms, such as Danio rerio , Drosophila melanogaster , and Caenorhabditis elegans , have been shown to possess similar anti-stress systems to mammals, suggesting that the Nrf2 antioxidant system represents an evolutionary conserved defense mechanism (38)

Nature (2018) 553:4616
