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If not effective, non-oral therapies such as levodopa-carbidopa intestinal gel (LCIG) delivered continuously through a percutaneous endoscopic gastro-jejunal (PEG-J) tube, or deep brain stimulation, represent the alternative [24]

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Finally, a pervasive sense of being overwhelmed by the cumulative burden of these multisystem symptoms can serve as a valuable clinical indicator for nociplastic pain [12, 75]