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In skin tissue, topical administration of rutin inhibited the IMQ-induced increases in reactive oxygen species, nitric oxide, and malondialdehyde, and significantly increased the IMQ-induced decreases in total antioxidant capacity, superoxide dismutase, and glutathione peroxidase

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In mice, researchers observed that MOTS-c in muscle and blood drops as the animals age, coinciding with the onset of age-related insulin resistance

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