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Heart failure is characterized by a loss of contractile function caused by energy depletion in mitochondria linked to a low level of UQ

Alassane-KpembiIKolf-ClauwMGauthierTAbramiRAbiolaFAOswaldIPet al

This effect is dose-dependent and duration-dependent, meaning higher doses and prolonged use increase deficiency risk

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Glutathione sepharose affinity chromatography The dialyzed 40 80% ammonium sulfate sample was applied onto a GSH-sepharose 4 fast flow column (8 1.4 cm) pre-equilibrated with 0.02 M Na-phosphate buffer pH 7.0 and set at a flow rate of 30 ml/h