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This divergence in clinical course parallels has been observed in human influenza, in which young persons without significant comorbidities tend to recover by Day 7, whereas older persons with comorbidities often clinically deteriorate

J Microsc Ultrastruct 4:123132

In summary, various nanocapsules and MOF-based nanoparticles have been shown to reverse the immunosuppressive tumor microenvironment either by reversing or inhibiting the immunosuppressive phenotype of MDSCs or by reducing the proportion of tumor-infiltrating MDSCs