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In AD pathology, abnormally modified Tau proteins regulate microglial activation: Hyperphosphorylated Tau enters microglia via CX3CR1 receptor-mediated endocytosis, activating Syk tyrosine kinase signaling to induce phagolysosomal dysfunction and pro-inflammatory mediator release (36,37)

Oxid Med Cell Longev 2021(1):8868941 Saba J et al (2022) Neuroinflammation in Huntingtons disease: a starring role for astrocyte and microglia

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Further reading: Vitamin B12 Supplements and Vitamin B12 Dosages Oral Vitamin B12 Supplements for Mild Nerve Disorders The previously tested protocols for the oral treatment of nerve disorders with B12 work with multiple doses per day

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