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If no pre-existing neuropathy is detected, clinicians should deliver education focused on early symptom detection and encourage prompt reporting of paresthesia, numbness, or motor changes

An intriguing novel study using the zebra fish model suggested that paclitaxel-induced neuropathy may depend on interactions between skin nerve endings and epidermal basal keratinocytes through the matrix metalloproteinase MMP-13 46

Box 5 presents recommendations from the consensus panel for HD

The membrane surface of a kernel vesicle can be coated with variable clumps of material (white arrowheads in left panel), and nearly always has an irregular, inner lining of material

In North America, the response rate to immune checkpoint inhibitors is 1520%, whereas in Asia, the response rate is slightly lower, at 1015% (26,27)