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When endotoxins like lipopolysaccharides (LPS) are no longer able to freely translocate from the intestinal lumen into the bloodstream, the systemic immune system is finally allowed to stand down

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Consistent with enhanced glutathione production, melatonin-treated ILC2s exhibited increased expression of GCLC and GCLM, enzymes that catalyze the rate-limiting steps in glutathione synthesis ( Figures 6E, F )