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It is also necessary to clarify the interconnectivity between disparate pathways within the internal milieu of the mitochondrial quality control system, to analyze the role of mitochondria and neurons in modulating the functionality of the brain and central nervous system, and to propose novel concepts and methodologies for the early diagnosis, prevention, and treatment of neurodegenerative diseases

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Authorship confirmation/contribution statement K Martino: Writing Original Draft, Data Curation, Investigation, Visualization A Nakhre: Writing Original Draft, Investigation RM Demarest: Conceptualization, Resources, Supervision (MDCK scatter assay) DM Devilbiss Conceptualization, Formal Analysis, Funding Acquisition, Methodology, Resources, Supervision, Validation, Writing Review & Editing Author(s) disclosure (Conflict of Interest) statement(s) The authors declare that they have no competing financial interests related to the work reported in this paper