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In HEK293 cells, the NC 1D -AR mutant, characterized by a C-tail truncation (in addition to an N-terminal truncation), did not alter the noradrenaline-induced calcium signaling, whereas the N-MutIL3 mutant, characterized by a mutated intracellular loop (in addition to an N-terminal truncation) demonstrated a decreased ability to increase intracellular calcium after stimulation with noradrenaline

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doi: 10.1177/0960327113493305

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