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Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis

Furthermore, this oxidative stress heavily impacts the central nervous system, contributing to the cognitive dysfunction commonly referred to as "brain fog." The brain is highly susceptible to oxidative damage due to its immense oxygen consumption and high lipid content

Neuroprotection of midbrain dopamine neurons by nicotine is gated by cytoplasmic Ca2+

However, there are many proteins that are indirectly activated by ROS, including transcription factors, such as hypoxia-inducible factor (HIF) and nuclear factor-B (NF-B), and kinases, like Src and AMP-activated protein kinase

[DOI] [PubMed] [Google Scholar] 25.Hellawell G.O., Turner G.D., Davies D.R., Poulsom R., Brewster S.F., Macaulay V.M