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The brain, sensing a drop in blood pressure and oxygen, initiates a "fight or flight" surge of adrenaline and norepinephrine, which causes the rapid, pounding heart rate (tachycardia), severe lightheadedness, and physical tremors associated with orthostatic intolerance

Nevertheless, a recent study found that the APOL1 alleles (G0, G1, and G2) can facilitate the passage of Ca 2+ through a lipid bilayer (218)