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They are primarily carried out by CYP450 1, 2, and 3 families

Variable phenotypic presentations of renal involvement in Fabry disease: a case series

TRAP1 is well studied in cancer since TRAP1 expression is tightly regulated in tumor cells (319), TRAP1 acts as a metabolic switch (320) by targeting and inhibiting succinate dehydrogenase (321), which is important for metabolic re-purposing and inflammatory responses (322)
[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Mayton H.S., Oliver C., Vaughn S.F., Loria R

Given that protease activity increases at an alkaline pH, the abnormal epidermal barrier function in rosacea might be associated with enhanced activation of epidermal proteases, especially kallikrein (KLK)-5
