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While preclinical findings are encouraging, human clinical evidence remains limited , and the compound should be viewed as a research-stage metabolic therapy rather than an established treatment for obesity or weight management

A concurrent vitamin D deficiency can increase the severity of mental health problems

NHS loading is 1mg hydroxocobalamin every two days for two weeks, then maintenance every two to three months for life when the cause is non-dietary

For deficiency or higher needs, an initial course of weekly injections may be recommended before moving to monthly maintenance

It is also worth seeking advice if you follow a vegan or vegetarian diet, take medications that may affect B12 absorption, or have a digestive condition that may increase your risk of deficiency