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The aforementioned empirical findings elucidated a novel mechanism underlying the therapeutic efficacy of simvastatin in GC and established a theoretical basis for the combined utilization of statins in GC immunotherapy
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Practically, distinguishing signalling from damage relies on complementary readouts: signalling proxies include reversible cysteine oxidation captured by redox proteomics, the redox state of peroxiredoxins, compartment-targeted H 2 O 2 reporters and phospho-signatures downstream of redox-sensitive kinases

Zhengsheng Zou, Fifth Medical Center of the PLA General Hospital, China Updates Copyright 2022 Zhao, Fu, Zhou, Cai, Huang, Gan, Zhang, Qian, Wang, Zhang, Wang, Xiang and Xie

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