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However, several clinical trials carried out to confirm the protective effect of vitamin E against the development of cancer have not been convincing

Histopathology 38 , 120134 (2001)

Studies have demonstrated a 50% increase in caspase-3 activity and a two-fold increase in Bax/Bcl-2 ratio with hesperidin treatment, leading to enhanced apoptosis in cancer cells

Therefore, the M1 or M2 classification is too simplistic to explain the true nature of in vivo macrophages, although these terms are still often used to indicate whether the macrophages in question are more pro-inflammatory or anti-inflammatory