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Levocarnitine is indicated in the treatment of primary systemic carnitine deficiency

However, it is important to recognise that whilst they are widely available, the regulatory framework for food supplements differs significantly from that of licensed medicines, and claims made about their efficacy should be evaluated critically against available evidence

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Inhibition of PPAR leads to serum acylcarnitine accumulation [190], whereas hepatic PPAR activation induced by energy deprivation or fibrates is associated with an increase in the carnitine concentration and a decrease in serum acylcarnitine accumulation [191, 192]

[published correction appears in PLoS One