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PMID: 120 XueYLuFChangZLiJGaoYZhouJet al

ICH S7A, released in 2001, outlines the core battery studies, discussed earlier

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Glutathione Stransferases (GSTs): GSTs lower the pKa of the GSH thiol to catalyze conjugation to electrophiles (Phase II metabolism), and some isoforms exhibit peroxidase-like activity toward lipid hydroperoxides, thereby linking detoxification with redox control