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There are several pharmacologically and medicinally significant compounds in ashwagandha, including withanolides, sitoindosides, and other alkaloids

Our orientation analyses indicate that WT -SNAP closely matches this arrangement, whereas M105I favors a horizontally biased conformation that is incompatible with symmetric positioning of -SNAP around the SNARE bundle

K.DrozakJ.WasikA.PereverzievaG.et al (2015)