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A gradual step-down gives the researcher time to implement dietary and behavioral strategies at each lower dose level, building habits that can partially compensate for the loss of pharmacological support
Matsuoka, T., Abe, M., & Kobayashi, H
They do not constitute proof of an effect in humans
While global Nrf2 activation may be beneficial, its specific effects in different cell types (e.g., potentially promoting ferritinophagy in macrophages) require careful consideration
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